Dosimetry for Radiopharmaceutical Therapy
STI/PUB/2065
ISBN
978-92-0-139523-8
299 pages | 75 figures | € 70.00 | Date published: 2024
This publication outlines the basic principles of radiation physics, types of imaging and non-imaging instrumentation, measurement of the administered activity, and calibration procedures and methods for obtaining quantitative information on the biodistribution of the radioactive drug used with radioisotopes for radiopharmaceutical therapy. It also describes methods for segmentation and registration of images acquired at different times, strategies for fitting and integration of activity measurements over the time of treatment, absorbed dose calculations and derived dosimetric indexes with methods to estimate the overall uncertainty of different radionuclide therapies. The aim of this book is to fill the existing gaps in education and training of medical physicists on methods for patient-specific dosimetry. The overall objective of this book is to highlight the available tools and methodologies to assure that radiopharmaceutical therapy is implemented through a dosimetry-guided individualized treatment approach.
Keywords:
Dosimetry for Radiopharmaceutical Therapy, RPT, Radiopharmaceuticals, Cancer, Radiation Dosimetry, Radiation Physics, Non-Imaging Instrumentation, Calibration Procedures, Quantitative Information, Biodistribution, Radioactive Drug, Radioisotopes, Segmentation, Registration of Images, Strategies for Fitting and Integration, Activity Measurements, Dose Calculations, Dosimetric Indexes, Radionuclide Therapies, Education and Training, Existing Gaps, Medical Physicists, Patient-Specific Dosimetry, Methodologies, Dosimetry-Guided Individualized Treatment Approach, Radiobiology, Traceability of Measured Dosimetry Data, Radioactive Decay, Radionuclide Emissions, Absorbed Dose Measurements, Metrology, Quantification of Activity, Tomographic Image Reconstruction, Dead Time Correction, Quantitative Imaging of Radionuclides, Imaging Surrogate Isotopes, Analysis of Temporally Varying Data, Pharmacokinetic Modelling, Clinical Radiobiological Modelling, Uncertainty Analysis, Dosimetry Protocol, Dose-Effect Relationships, Clinical Trials, Review
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