Copper-64 Radiopharmaceuticals: Production, Quality Control and Clinical Applications

INTERNATIONAL ATOMIC ENERGY AGENCY

IAEA Radioisotopes and Radiopharmaceuticals Series No. 7

English STI/PUB/1961 | 978-92-0-129621-4

125 pages | 55 figures | € 42.00 | Date published: 2022

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Description

Positron emission tomography (PET) is an important clinical tool, and with its longer half-life, copper-64 has several unique attributes that make it a multi-purpose radionuclide with many potential applications. Additionally, copper as a trace element plays a pivotal role in several human metabolic and pathologic diseases and is involved in malignant cells biochemistry pathways. This offers the opportunity for scientists to explore the theranostic capabilities of copper-64. This current publication, arising from an IAEA Coordinated Research Project, describes the biochemical and radiopharmaceutical aspects of copper-64, and its clinical applications, with specific guidelines and methods for the production of copper-64 chloride, peptide and monoclonal antibody radiopharmaceuticals. It is expected to be of use to all professionals involved in the field by specifying ideal production, formulation and quality control methods.

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Keywords

IAEA Radioisotopes and Radiopharmaceuticals, Copper-64 Radiopharmaceuticals, Production, Quality Control, Clinical Applications, Isotopes, Therapeutic Use, Biochemical and Radiopharmaceutical Aspects, Guidelines, Methods, Copper-64 Chloride, Peptide, Monoclonal Antibody Radiopharmaceuticals, Chelating Ligands, Antibody Conjugations, Antibody Radiolabelling, Dichloride Radiopharmaceuticals, Dosimetry, Positron Emission Tomography, PET, Clinical Tool, IAEA Coordinated Research Project, Standard Operation Procedures, Advances, Copper Chelation Chemistry, Biological Targets, Preclinical Evaluation, Biological Evaluation, Immunomolecules, Biological Systems, Molecular and Cellular Level, Biochemistry