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          Evaluation and Validation of Radioisotopes Generators-Based Radiotracer for Industrial Applications

          Closed for proposals

          Project Type

          Coordinated Research Project

          Project Code

          F22044

          CRP

          1426

          Approved Date

          6 March 2007

          Status

          Closed

          Start Date

          1 July 2007

          Expected End Date

          30 June 2011

          Completed Date

          29 September 2011

          Description

          Radiotracers are widely applied in industries to optimize processes, solve problems, improve product quality, save energy and reduce pollution. However, the radiotracer services are not readily available in many developing countries, mainly because of problems in timely availability of radiotracers as well as their suitability for use in harsh conditions of industrial processes. Producing and using long shelf-life radionuclide generators in a practical solution to the problem. The CRP will identify and coordinate development of industrial radionuclide generators and validate the radionuclide generator-based radiotracers for applications in industrial investigations with emphasis on applicability in field conditions. Guidelines for production of various radiotracers based ort the radionuclide generators will be also developed. The CRP will contribute to larger utilization of industrial radiotracer technology in MS through -the enhanced availability of radionuclide generator- based radiotracers.

          Objectives

          To investigate the potential of radionuclide generators for industrial radiotracer applications with particular focus on usage in developing MS.

          Specific objectives

          To develop techniques for the production of various industrial radiotracers from the IRG based radionuclides

          To develop portable systems for production of specific radiotracers in connection with the IRGs

          To develop techniques for enhancement of long-term stability of the IRGs to extend their shelf-lives

          To provide guidelines for the preparation and validation of the IRG based radiotracers

          Impact

          The generators are of a huge importance and in many cases the only way to have available radiotracers for industrial applications due to the difficulties to obtain radionuclides for radiotracers applications especially in developing MSs. In TC cycle 2012-2013, the technologies and methodologies developed within the CRP will be applied in two regional TC projects (RCA and AFRA) and three national TC projects (in Asia-Pacific, Africa and Latin America regions). Beside these TC projects, technologies and methodologies developed within the CRP will be applied in MSs having participated in the CRP, but also transferred and applied in many MSs not involved in the CRP, for their national activities.

          Relevance

          The CRP is relevant to the research priorities of the participating countries . They expressed high interest and involvement.

          CRP Publications

          Type

          Publication in Eur J Nucl Med Mol Imaging 37(4) (2010) 834.

          Year

          2010

          Description

          PET/CT imaging of osteoblastic bone metastases with 68Ga-bisphosponates - first in human study.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M. Fellner and al.

          Type

          Publication in Chromatographia, Volume 69, Issue 5 (2009), 497-501

          Year

          2009

          Description

          An alumina based 99Mo-99mTc generator to produce 99mTc in organic medium suitable for Industrial Radiotracer Applications

          Country/Organization

          India/ BARC/ A.Dash and al

          Type

          Proceedings of 5th international conference on tracers and tracing methods , Brazil, ISBN N° 978-85-61905-01-09

          Year

          2008

          Description

          Axial mixing performance of continuous phase in a pulsed sieve plate extraction column using gallium chloride as radiotracer

          Country/Organization

          Pakistan/ PINSTECH/ G.U.Din and al.

          Type

          publication in European Physical Journal (Web of Conferences).

          Year

          2012

          Description

          Investigation of liquid phase axial dispersion in Taylor bubble flow by radiotracer residence time distribution analysis,

          Country/Organization

          Pakistan/ PINSTECH/ R. Chughtai and al.

          Type

          publication in European Physical Journal (Web of Conferences).

          Year

          2012

          Description

          Radiotracer investigations to study the hydrodynamic characteristics of continuous phase in a pulsed sieve plate extraction column,

          Country/Organization

          Pakistan/ PINSTECH/ G.U.Din and al.

          Type

          Proceedings of 5th international conference on energy and advancements in process engineering (ICEAPE 2010), Pakistan

          Year

          2010

          Description

          Liquid phase axial dispersion study of Taylor bubble flow in a horizontal tube by radiotracer RTD analysis

          Country/Organization

          Pakistan/PINSTECH/ W.Iqbal and al.

          Type

          Publication in Bioorg Med Chem Let. 18 (2008) 5364–5367.

          Year

          2008

          Description

          NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ J.Riss and al.

          Type

          Publication in Chemistry. 16/24 (2010) 7174-85.

          Year

          2010

          Description

          A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for Positron Emission Tomography.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ J. Notni and al.

          Type

          Publication in Nukleonika, Vol.56, No.1, 2011, p.77-80

          Year

          2011

          Description

          Ge-68/Ga-68 radioisotope generator as a source of radiotracers for water flow investigations

          Country/Organization

          Poland/ Institute of Radiochemistry and Technology/ J.Palige and al.

          Type

          Publication in Journal of Chromatography A, 1220,82-91(2012).

          Year

          2012

          Description

          Ammonium molybdophosphate impregnated alumina microspheres as a new generation sorbent for chromatographic 137Cs/137mBa generator

          Country/Organization

          India/ BARC/ A.Dash and al

          Type

          Publication in Nucl Med Biol 35 (2008) 721-724.

          Year

          2008

          Description

          Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M.Asti and al.

          Type

          M.S. Thesis, Pakistan Institute of Engineering and Applied Sciences,

          Year

          2011

          Description

          Liquid phase axial dispersion in Taylor bubble flow by residence time distribution analysis in a horizontal tube,

          Country/Organization

          Pakistan/ PINSTECH/ W. Iqbal

          Type

          Publication in J Nucl Med. 48 (2007) 1741-1748.

          Year

          2007

          Description

          Processing of generator-produced 68Ga for medical application.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ KP. Zhernosekov and al.

          Type

          Publication in Curr Top Med Chem. 10/16 (2010) 1633-68.

          Year

          2010

          Description

          The Renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical chemistry.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Roesch and al.

          Type

          PhD thesis, Pakistan Institute of Engineering and Applied Sciences,

          Year

          2009

          Description

          Radiotracer investigations and modelling of the hydrodynamic characteristics of a liquid-liquid extraction pulsed column

          Country/Organization

          Pakistan/ PINSTECH/ G.U. Din

          Type

          Applied Radiation Isotopes 69 (2011) 942-6

          Year

          2011

          Description

          Improved column-based radiochemical processing of the generator produced 68Ga

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Loktionova NS and al.

          Type

          Proceedings of Dalton Transactions 40/23 (2011) 6104-6111

          Year

          2011

          Description

          Generator-based PET radiopharmaceuticals for molecular imaging of tumours: On the way to THERANOSTICS

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ R?sch F and al.

          Type

          Proceedings of 5th International Conference on Tracers and Tracing Methods?, TRACER5, Tiradentes, Brazil

          Year

          2008

          Description

          Industrial radiotracer generators

          Country/Organization

          Institute for Energy Technology (IFE), Kjeller, Norway/ Kristin Fure and al.

          Type

          Proceedings of 6th International Conference on Tracers and Tracing Methods?, TRACER6, Oslo, Norway

          Year

          2011

          Description

          Using isotopes produced from radionuclide generators as tracers for membrane installation investigations

          Country/Organization

          Poland/ Institute of Radiochemistry and Technology/ A.Miskiewicz and al.

          Type

          Publication in Eur J Nucl Med Mol Imaging. 37(10) (2010) 1935-42.

          Year

          2010

          Description

          Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ O.Thews and al.

          Type

          Publication in Contrast Media Mol Imaging. 6(6) (2011) 492-498.

          Year

          2011

          Description

          A convenient multi-gram scale synthesis procedure of functionalized, bivalent, DO2A-based chelators.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Burchardt C and al.

          Type

          Publication in Nuclear Medicine and Biology 38 (2011) 393–398

          Year

          2011

          Description

          Potential use of 68Ga-apo-transferrin as a PET imaging agent for detecting Staphylococcus aureus infection.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ V. Kumar and al.

          Type

          Publication in Radiochimica Acta 99/1 (2011) 43-51.

          Year

          2011

          Description

          Comparison of different phosphorus-containing ligands complexing 68Ga for PET-imaging of bone metabolism

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Fellner M and al.

          Type

          Transactions of the Korean Nuclear Society Autumn MeetingGyeongju, Korea, October 27-28, 2011

          Year

          2011

          Description

          Feasibility Study on the Radionuclide Generator Based Radiotracer for the Industrial Process Diagnosis Technology

          Country/Organization

          Korea/ KAERI/ S.H Jung and al.

          Type

          Book : Radionuclide Generators. Handbook of Nuclear Chemistry, Vértes A, Nagy S, Klencsár Z, Lovas RG, R?sch F (eds.) Vol. 4, pp 1935-1976, Second edition, Springer, 2011

          Year

          2011

          Description

          Radionuclide Generators. Handbook of Nuclear Chemistry second edition

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ R?sch F and al.

          Type

          Publication in Applied Radiation and Isotopes, 70(1):51-58(2012).

          Year

          2012

          Description

          Development of a 99Mo/99mTc generator using alumina microspheres for industrial radiotracer applications

          Country/Organization

          India/ BARC/ A.Dash and al

          Type

          Proceedings of 6th International Conference on Tracers and Tracing Methods?, TRACER6, Oslo, Norway and publication in EPJ Web of Conferences

          Year

          2011

          Description

          Development of an oil tracer labelled with 137mBa

          Country/Organization

          Institute for Energy Technology (IFE), Kjeller, Norway/ Liv Stavsetra and al.

          Type

          IAEA-TEC-DOC Radioisotopes and radiopharmaceuticals, Series 2: Production of Long Lived Parent Radionuclides for Generators: 68Ge, 82Sr, 90Sr and 188W, ISSN 2077–6462 ; no. 2, STI/PUB/1436, ISBN 978–92–0–101110–7.

          Year

          2010

          Description

          Production, radiochemical processing and quality evaluation of Ge-68

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Roesch and al.

          Type

          Norwegian Patent Application No. 20110816,

          Year

          2011

          Description

          Radioactively labelled organic tracer, its use and a method for its production

          Country/Organization

          Institute for Energy Technology (IFE), Kjeller, Norway/ T. Bjornstad and al.

          Type

          Publication in Separation Science and Technology journal

          Year

          2012

          Description

          Development of a 68Ge/68Ga Generator to avail 68Ga in Organic Medium for Industrial Radiotracer Applications

          Country/Organization

          India/ BARC/ A.Dash and al

          Type

          Publication in Appl. Radiat Isot,

          Year

          2012

          Description

          Radiolabeling of DOTATOC with the longer-lived, generator-derived positron emitter 44Sc

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M Pruszynski and al.

          Type

          Publication in Mol Imaging Biol. 13/5 (2011) 985-994

          Year

          2011

          Description

          Thews O. Assessing p-glycoprotein (Pgp) activity in vivo utilizing 68Ga-Schiff base complexes

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Fellner M and al.

          Type

          Master of Science Thesis

          Year

          2010

          Description

          Development of radiotracer generators for use in industrial processes – the case of 137Cs ? 137mBa

          Country/Organization

          Institute for Energy Technology (IFE), Kjeller, Norway, and Chalmers University of Technology, Gothenburg, Sweden / Sofie Fredriksson + Tor Bjornstad

          Type

          Publication in Radiochimica Acta 98/3 (2010) 157-160.

          Year

          2010

          Description

          Efficient post-processing of aqueous generator eluates facilitates 68Ga-labelling under anhydrous conditions.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Zoller and al.

          Type

          Publication in Bioorg Med Chem Lett 19(13) (2009) 3498-501.

          Year

          2009

          Description

          [68Ga]Ga-DO(2)A-(OBu-l-tyr)(2): Synthesis, 68Ga-radiolabeling and in vitro studies of a novel 68Ga-DO(2)A-tyrosine conjugate as potential tumor tracer for PET.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ C.BUrchardt and al.

          Type

          publication in Radiochimica Acta 98/8 (2010) 519-523.

          Year

          2010

          Description

          Studies towards the development of lipophilic bifunctional N3S3 chelators for 68Ga.

          Country/Organization

          Germany/ Institute of Nuclear chemistry. Univ. Mainz/ P.Riss and al.

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