Evaluation and Validation of Radioisotopes Generators-Based Radiotracer for Industrial Applications
Closed for Proposals
Project Type
Coordinated Research ProjectProject Code
F22044
CRP
1426
Approved Date
06/03/2007Project Status
ClosedStart Date
01/07/2007Expected End Date
30/06/2011Completed Date
29/09/2011Description
Radiotracers are widely applied in industries to optimize processes, solve problems, improve product quality, save energy and reduce pollution. However, the radiotracer services are not readily available in many developing countries, mainly because of problems in timely availability of radiotracers as well as their suitability for use in harsh conditions of industrial processes. Producing and using long shelf-life radionuclide generators in a practical solution to the problem. The CRP will identify and coordinate development of industrial radionuclide generators and validate the radionuclide generator-based radiotracers for applications in industrial investigations with emphasis on applicability in field conditions. Guidelines for production of various radiotracers based ort the radionuclide generators will be also developed. The CRP will contribute to larger utilization of industrial radiotracer technology in MS through -the enhanced availability of radionuclide generator- based radiotracers.
Objectives
To investigate the potential of radionuclide generators for industrial radiotracer applications with particular focus on usage in developing MS.
Specific Objectives
To develop techniques for the production of various industrial radiotracers from the IRG based radionuclides
To develop portable systems for production of specific radiotracers in connection with the IRGs
To develop techniques for enhancement of long-term stability of the IRGs to extend their shelf-lives
To provide guidelines for the preparation and validation of the IRG based radiotracers
Impact
The generators are of a huge importance and in many cases the only way to have available radiotracers for industrial applications due to the difficulties to obtain radionuclides for radiotracers applications especially in developing MSs. In TC cycle 2012-2013, the technologies and methodologies developed within the CRP will be applied in two regional TC projects (RCA and AFRA) and three national TC projects (in Asia-Pacific, Africa and Latin America regions). Beside these TC projects, technologies and methodologies developed within the CRP will be applied in MSs having participated in the CRP, but also transferred and applied in many MSs not involved in the CRP, for their national activities.
Relevance
The CRP is relevant to the research priorities of the participating countries . They expressed high interest and involvement.
CRP Publications
Institute for Energy Technology (IFE), Kjeller, Norway, and Chalmers University of Technology, Gothenburg, Sweden / Sofie Fredriksson + Tor Bjornstad
Master of Science Thesis
2010
Development of radiotracer generators for use in industrial processes – the case of 137Cs ? 137mBa
Institute for Energy Technology (IFE), Kjeller, Norway/ T. Bjornstad and al.
Norwegian Patent Application No. 20110816,
2011
Radioactively labelled organic tracer, its use and a method for its production
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M. Fellner and al.
Publication in Eur J Nucl Med Mol Imaging 37(4) (2010) 834.
2010
PET/CT imaging of osteoblastic bone metastases with 68Ga-bisphosponates - first in human study.
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M.Asti and al.
Publication in Nucl Med Biol 35 (2008) 721-724.
2008
Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC.
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Roesch and al.
IAEA-TEC-DOC Radioisotopes and radiopharmaceuticals, Series 2: Production of Long Lived Parent Radionuclides for Generators: 68Ge, 82Sr, 90Sr and 188W, ISSN 2077–6462 ; no. 2, STI/PUB/1436, ISBN 978–92–0–101110–7.
2010
Production, radiochemical processing and quality evaluation of Ge-68
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Fellner M and al.
Publication in Mol Imaging Biol. 13/5 (2011) 985-994
2011
Thews O. Assessing p-glycoprotein (Pgp) activity in vivo utilizing 68Ga-Schiff base complexes
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ J. Notni and al.
Publication in Chemistry. 16/24 (2010) 7174-85.
2010
A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric 68Ga tracers for Positron Emission Tomography.
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Loktionova NS and al.
Applied Radiation Isotopes 69 (2011) 942-6
2011
Improved column-based radiochemical processing of the generator produced 68Ga
Pakistan/PINSTECH/ W.Iqbal and al.
Proceedings of 5th international conference on energy and advancements in process engineering (ICEAPE 2010), Pakistan
2010
Liquid phase axial dispersion study of Taylor bubble flow in a horizontal tube by radiotracer RTD analysis
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Burchardt C and al.
Publication in Contrast Media Mol Imaging. 6(6) (2011) 492-498.
2011
A convenient multi-gram scale synthesis procedure of functionalized, bivalent, DO2A-based chelators.
India/ BARC/ A.Dash and al
Publication in Journal of Chromatography A, 1220,82-91(2012).
2012
Ammonium molybdophosphate impregnated alumina microspheres as a new generation sorbent for chromatographic 137Cs/137mBa generator
Poland/ Institute of Radiochemistry and Technology/ J.Palige and al.
Publication in Nukleonika, Vol.56, No.1, 2011, p.77-80
2011
Ge-68/Ga-68 radioisotope generator as a source of radiotracers for water flow investigations
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ O.Thews and al.
Publication in Eur J Nucl Med Mol Imaging. 37(10) (2010) 1935-42.
2010
Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Zoller and al.
Publication in Radiochimica Acta 98/3 (2010) 157-160.
2010
Efficient post-processing of aqueous generator eluates facilitates 68Ga-labelling under anhydrous conditions.
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ J.Riss and al.
Publication in Bioorg Med Chem Let. 18 (2008) 5364–5367.
2008
NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging.
Institute for Energy Technology (IFE), Kjeller, Norway/ Liv Stavsetra and al.
Proceedings of 6th International Conference on Tracers and Tracing Methods?, TRACER6, Oslo, Norway and publication in EPJ Web of Conferences
2011
Development of an oil tracer labelled with 137mBa
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ R?sch F and al.
Book : Radionuclide Generators. Handbook of Nuclear Chemistry, Vértes A, Nagy S, Klencsár Z, Lovas RG, R?sch F (eds.) Vol. 4, pp 1935-1976, Second edition, Springer, 2011
2011
Radionuclide Generators. Handbook of Nuclear Chemistry second edition
Pakistan/ PINSTECH/ G.U.Din and al.
Proceedings of 5th international conference on tracers and tracing methods , Brazil, ISBN N° 978-85-61905-01-09
2008
Axial mixing performance of continuous phase in a pulsed sieve plate extraction column using gallium chloride as radiotracer
Pakistan/ PINSTECH/ G.U. Din
PhD thesis, Pakistan Institute of Engineering and Applied Sciences,
2009
Radiotracer investigations and modelling of the hydrodynamic characteristics of a liquid-liquid extraction pulsed column
Korea/ KAERI/ S.H Jung and al.
Transactions of the Korean Nuclear Society Autumn MeetingGyeongju, Korea, October 27-28, 2011
2011
Feasibility Study on the Radionuclide Generator Based Radiotracer for the Industrial Process Diagnosis Technology
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ P.Riss and al.
publication in Radiochimica Acta 98/8 (2010) 519-523.
2010
Studies towards the development of lipophilic bifunctional N3S3 chelators for 68Ga.
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ KP. Zhernosekov and al.
Publication in J Nucl Med. 48 (2007) 1741-1748.
2007
Processing of generator-produced 68Ga for medical application.
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ F.Roesch and al.
Publication in Curr Top Med Chem. 10/16 (2010) 1633-68.
2010
The Renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical chemistry.
India/ BARC/ A.Dash and al
Publication in Chromatographia, Volume 69, Issue 5 (2009), 497-501
2009
An alumina based 99Mo-99mTc generator to produce 99mTc in organic medium suitable for Industrial Radiotracer Applications
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ Fellner M and al.
Publication in Radiochimica Acta 99/1 (2011) 43-51.
2011
Comparison of different phosphorus-containing ligands complexing 68Ga for PET-imaging of bone metabolism
Pakistan/ PINSTECH/ W. Iqbal
M.S. Thesis, Pakistan Institute of Engineering and Applied Sciences,
2011
Liquid phase axial dispersion in Taylor bubble flow by residence time distribution analysis in a horizontal tube,
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ V. Kumar and al.
Publication in Nuclear Medicine and Biology 38 (2011) 393–398
2011
Potential use of 68Ga-apo-transferrin as a PET imaging agent for detecting Staphylococcus aureus infection.
Pakistan/ PINSTECH/ G.U.Din and al.
publication in European Physical Journal (Web of Conferences).
2012
Radiotracer investigations to study the hydrodynamic characteristics of continuous phase in a pulsed sieve plate extraction column,
Poland/ Institute of Radiochemistry and Technology/ A.Miskiewicz and al.
Proceedings of 6th International Conference on Tracers and Tracing Methods?, TRACER6, Oslo, Norway
2011
Using isotopes produced from radionuclide generators as tracers for membrane installation investigations
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ M Pruszynski and al.
Publication in Appl. Radiat Isot,
2012
Radiolabeling of DOTATOC with the longer-lived, generator-derived positron emitter 44Sc
Institute for Energy Technology (IFE), Kjeller, Norway/ Kristin Fure and al.
Proceedings of 5th International Conference on Tracers and Tracing Methods?, TRACER5, Tiradentes, Brazil
2008
Industrial radiotracer generators
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ C.BUrchardt and al.
Publication in Bioorg Med Chem Lett 19(13) (2009) 3498-501.
2009
[68Ga]Ga-DO(2)A-(OBu-l-tyr)(2): Synthesis, 68Ga-radiolabeling and in vitro studies of a novel 68Ga-DO(2)A-tyrosine conjugate as potential tumor tracer for PET.
Germany/ Institute of Nuclear chemistry. Univ. Mainz/ R?sch F and al.
Proceedings of Dalton Transactions 40/23 (2011) 6104-6111
2011
Generator-based PET radiopharmaceuticals for molecular imaging of tumours: On the way to THERANOSTICS
India/ BARC/ A.Dash and al
Publication in Applied Radiation and Isotopes, 70(1):51-58(2012).
2012
Development of a 99Mo/99mTc generator using alumina microspheres for industrial radiotracer applications
India/ BARC/ A.Dash and al
Publication in Separation Science and Technology journal
2012
Development of a 68Ge/68Ga Generator to avail 68Ga in Organic Medium for Industrial Radiotracer Applications
Pakistan/ PINSTECH/ R. Chughtai and al.
publication in European Physical Journal (Web of Conferences).
2012
Investigation of liquid phase axial dispersion in Taylor bubble flow by radiotracer residence time distribution analysis,