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          Human Health Campus
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          Human Health Campus

          Paradoxical pattern in a patient with previous myocardial infarction

          Teaching Case

          Case presentation:

          • Female.
          • 66 y.o.
          • Previous MI.
          • Dyspnea and non-specific chest discomfort.
          • ECG: Q waves V3-V5.
          • Echo: LVEF 48%, apical hypokinesia.
          • Referred for MPS w/ pharmacologic stress.
          • Dipyridamole + rest (2-day protocol), 99mTc-MIBI.
          • Well tolerated, no symptoms, no ECG changes, BP 130/80 mmHg at rest, 120/75 mmHg during the test.

          Teaching points:

          • Myocardial necrosis with a paradoxical pattern (PP) is observed in a few proportion of patients with myocardial necrosis.
          • Necrotic areas with PP have preserved myocardial flow, owing to either patency of the culprit artery, or the presence of collateral circulation to this territory when the artery is occluded.
          • Patients exhibiting a PP on MPS with Tc-99m-labeled tracers have a better prognosis and better LV function than patients with a non-PP pattern in necrotic myocardial regions.
          • PP can also be observed as an artefact in studies with low-count statistics, or if there is dominant attenuation during the stress portion.
          • QC data should be always checked before interpreting MPS.

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