Nanosized Delivery Systems for Radiopharmaceuticals
Closed for Proposals
Project Type
Coordinated Research ProjectProject Code
F22064
CRP
2002
Approved Date
13 November 2013Project Status
ClosedStart Date
4 April 2014Expected End Date
4 April 2019Completed Date
29 October 2019Description
The aim of this CRP is to provide significant improvement in the delivery of therapeutic radiopharmaceuticals through the use of nanotechnology. It is expected to result in new nanoparticles capable of forming stable bonds with diagnostic and therapeutic radioisotopes, and with tumour specific biomolecules and proteins (including monoclonal antibodies) leading to well-defined delivery devices. Such nano constructs built from radiation-synthesized polymeric nano particles could be potentially capable of reaching and selectively penetrating the tumour sites, thus affording highly effective molecular imaging and therapeutic tools to combat various forms of human cancers. The proposed CRP will provide tremendous benefits to MS because the nanosized diagnostic and therapeutic agents that are planned to be developed might be potentially used in alleviating pain and suffering of human patients globally.
Objectives
The overall objective of this CRP is to exploit the unique properties of materials at the nanometer scale for developing nanocarriers of radioactivity capable of selectively targeting and penetrating cancerous cells.
Specific Objectives
a; To synthesize polymeric (both synthetic and natural) nanoparticles capable of forming in vitro and in vivo-stable bonds, through chelate interactions, with diagnostic and therapeutic radioisotopes—for the creation of new generation of nanoparticle-based tumor specific radiopharmaceuticals.
b; To formulate tumor specific proteins (including monoclonal antibodies) and generate well-defined nanoparticles, through radiation methods, for use in conjugation reactions with diagnostics and therapeutic radioisotopes for the generation of nanosized tumor specific radiopharmaceuticals.
c; To formulate nanoparticles derived from inherently diagnostic/ therapeutic radioisotopes and to conjugate them with tumor specific peptide(s)—in order to generate radioactive nanoceuticals for diagnostic imaging and therapy.
d; To develop a functional in vivo platform for efficient testing of various radiolabeled nanoconstructs using animal models that mimic human tumors—all aimed at clinical translation of diagnostic/therapeutic efficacy from animal for human applications.
Impact
The participants suggested initiation of a new CRP for completion of preclinical studies of the selected nanoconstructs (with focus on Ga-68, Lu-177 and Au-198 radionuclides)
The participants emphasized on initiation of a new CRP on one selected nanoconstruct from this CRP (MGF 198AuNPs)with completed preclinical results) through IAEA NAHU, nuclear medicine section
Instant initiation of an IAEA publication on the ‘Development of radiolabeled nanoparticles for theranostic applications” as an outcome of this CRP with the help of the participants and world-class scientists
Preparation of an IAEA publication on “Guidelines on the development of human tumour models for preclinical studies of radiopharmaceuticals”
A new activity on the clinical evaluation of chemical and radiation produced 99mTc-Nanocolloids for sentinel node scintigraphy through IAEA NAHU, nuclear medicine section
The participants agreed that the report to be kept confidential among the participants and not to be shared publicly. As soon as the participants announce their willingness for public access, the scientific secretary will initiate publishing the report as a ‘working material”
Relevance
The currently used therapeutic agents in nuclear medicine continue to pose medical challenges mainly due to the limited uptake of radiocompound within tumour sites. This limited accumulation accounts for the fact that current beta-emitting therapeutic nuclear medicine agents have failed to deliver optimum therapeutic payloads at tumour sites. Actually, no other radiolabelled therapeutic agent has been capable to get close to the remarkably high target accumulation that was demonstrated by the long-lasting radionuclide I-131 in thyroid cancer. This means that metastases of several different types of aggressive cancers cannot be controlled, making it difficult to treat cancer patients. Therefore, new delivery modalities that result in (i) effective delivery of therapeutic probes with optimum payloads, site specifically at the tumour sites, minimal/tolerable systemic toxicity, and (ii) higher tumour retention, would bring about a clinically measurable shift in the way cancers are diagnosed and treated.
Nanotechnology has the potential to bring about this paradigm shift in the early detection and therapy of various forms of human cancers because radioactive nanoparticles of optimum sizes for penetration across tumour cell membranes can be engineered through a myriad of interdisciplinary approaches, involving teams of experts from nuclear medicine, materials sciences, physics, chemistry, tumour biology and oncologists. Therefore, the overall approach which encompasses application of nanoparticulate radioactive probes in combination with polymeric nanomaterials has a realistic potential to generate the next generation of tumour specific theranostic nanoradiopharmaceuticals and minimize/eliminate delivery and tumour accumulation problems associated with the existing traditional nuclear medicine agents.
CRP Publications
THAILAND
AWARDS
2014
Best Poster Presentation Award: WONGKRONGSAK, S., TANGTHONG, T., PASANPHAN, W. (2014, October 5-9). Electron beam induced water-soluble silk fibroin nanoparticles as a natural antioxidant and reducing agent for green synthesis of gold nanocolloid. Poster presentation (The best poster presentation award). The 11th Meeting of the Ionizing Radiation and Polymer Symposium (IRAP), Jeju, Korea.
ITALY
full paper
2016
Adamo G, Grimaldi N, Campora S, Bulone D, Bondì ML, Al-Sheikhly M, et al. Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery. Molecules (Basel, Switzerland). 2016;21(11):1594. doi: 10.3390/molecules21111594.
USA
full paper
2016
Katti KV. Renaissance of nuclear medicine through green nanotechnology: functionalized radioactive gold nanoparticles in cancer therapy—my journey from chemistry to saving human lives. 2016;309(1):5-14. doi: 10.1007/s10967-016-4888-0. PubMed PMID: pub.1021561037.
MEXICO
full paper
2014
Ocampo García B.E., Miranda-Olvera R.M., Santos-Cuevas C.L., García-Becerra R., Azorín-Vega E.P., Ordaz-Rosado D., (2014). In vitro Decrease of the BCL-2 Protein Levels in Lymphoma Cells Induced by Gold Nanoparticles and Gold Nanoparticles-Anti-CD20, Nanoscience & Technology, 1(3): 1-6.
ITALY
GRADUATED STUDENT THESIS
2015
ROBERTA ROSALIA RUSSO, MSc Thesis “Trasporto e rilascio intracellulare di antimiR nella Terapia Oncologica”.
MEXICO
PATENTS
Inventors: E. Morales-Avila, B. Ocampo-García, G. Ferro-Flores, B. Gibbens-Bandala, M.Trujillo-Nolasco Title:177Lu-DOTA-HA-PLGA(MTX) como un nuevo nanoradiofármaco para terapia dual de procesos inflamatorios que sobreexpresan receptores CD44. Patent number: MX/a/2018/006934
USA
full paper
2017
Sakr TM, Korany M, Katti KV. Selenium nanomaterials in biomedicine—An overview of new opportunities in nanomedicine of selenium. Journal of Drug Delivery Science and Technology. 2018;46:223-33. doi: 10.1016/j.jddst.2018.05.023.
USA
full paper
2015
Owen A, Dufès C, Moscatelli D, Mayes E, Lovell JF, Katti KV, et al. The application of nanotechnology in medicine: treatment and diagnostics. Nanomedicine. 2014;9(9):1291-4.
POLAND
GRADUATED STUDENT THESIS
2019
RURARZ BEATA, Ph.D Thesis “Polymer-based nanocarriers of biologically active compounds”
POLAND
GRADUATED STUDENT THESIS
2013
KEDZIOR JOANNA, MSc Thesis “Radiation synthesis of stabilized silver nanoparticles - process optimization”
Italy
Presentation
2014
"m. chinol, g. caviglioli, s. baldassari, e. russo, b. parodi, a. carollo, g. paganelli, “a new conjugate of human albumin and p-scn-bn-dota for radioguided occult lesion localization in breast cancer(roll)” j. nucl. med, 2014; 55(suppl. 1): 613 "
USA
full paper
2016
Gamal-Eldeen AM, Moustafa D, El-Daly SM, El-Hussieny EA, Saleh S, Khoobchandani M, et al. Photothermal therapy mediated by gum Arabic-conjugated gold nanoparticles suppresses liver preneoplastic lesions in mice. Journal of photochemistry and photobiology B, Biology. 2016;163:47-56.
POLAND
GRADUATED STUDENT THESIS
2015
ADAMSKI WIKTOR, BSc Thesis “Polymeric carriers of active substances for use in radiotherapy”
BRAZIL
GRADUATED STUDENT THESIS
2018
JESSICA LEAL, MSc Thesis "Synthesis and characterization of radioactive gold nanoparticle (198Au-NPs) with BSA for biomedical purposes”
POLAND
GRADUATED STUDENT THESIS
2016
MAKASEWICZ KATARZYNA, M.Sc Thesis “Radiation synthesis of poly(ethyleneimine) nanogels - thesis with collaboration with Palermo”
POLAND
full paper
2016
G.H.C. Varca, S. Kadlubowski, M. Wolszczak, A.B. Lug?o, J.M. Rosiak, P. Ulanski, Synthesis of papain nanoparticles by electron beam irradiation – A pathway for controlled enzyme crosslinking, International Journal of Biological Macromolecules 92, 2016, 654–659, DOI:10.1016/j.ijbiomac.2016.07.070
BRAZIL
full paper
2018
Queiroz RG, Varca GHC, Kadlubowski S, Ulanski P, Lug?o AB. Radiation-synthesized protein-based drug carriers: Size-controlled BSA nanoparticles. International Journal of Biological Macromolecules. 2016;85:82-91. doi: 10.1016/j.ijbiomac.2015.12.074.
MEXICO
GRADUATED STUDENT THESIS
2014
ROSALBA MONSERRAT MIRANDA OLVERA, BSc. Thesis “Sistema multivalente para la terapia de linfomas no-Hodking basado en Anti CD-20 conjugado a nanopartículas de oro”.
POLAND
GRADUATED STUDENT THESIS
WOJTCZAK EDYTA, MSc Thesis “Synthesis and properties of gold nanoparticles stabilized using hydrophilic polymers”
Iran
full paper
2016
14. Yousef Fazaeli, Shahzad Feizi, Amir R Jalilian, Ali Hejrani. Grafting of [64Cu]-TPPF20 Porphyrin Complex on Functionalized Nano-porous MCM-41 Silica as a Potential Cancer Imaging Agent, Applied Radiat Isotopes, 2016 ,112:13-9.
Mexico
Research paper
(2014).
Ocampo García B.E., Miranda-Olvera R.M., Santos-Cuevas C.L., García-Becerra R., Azorín-Vega E.P., Ordaz-Rosado D., (2014). In vitro Decrease of the BCL-2 Protein Levels in Lymphoma Cells Induced by Gold Nanoparticles and Gold Nanoparticles-Anti-CD20, Nanoscience & Technology, 1(3): 1-6
POLAND
GRADUATED STUDENT THESIS
2016
SOWINSKI SEBASTIAN, M.Sc Thesis “ Radiolysis of papain in aqueous solutions
USA
full paper
2017
Gamal-Eldeen AM, Moustafa D, El-Daly SM, Abo-Zeid MAM, Saleh S, Khoobchandani M, Katti KV. Gum Arabic-encapsulated gold nanoparticles for a non-invasive photothermal ablation of lung tumor in mice. Biomedicine & Pharmacotherapy. 2017;89:1045-54. doi: https://doi.org/10.1016/j.biopha.2017.03.006.
USA
full paper
2019
Al-Yasiri AY. Katti, K.V., Loyalka, S, et al, Estimation of Tumor and Local Tissue Dose in Gold Nanoparticles Radiotherapy for Prostate Cancer.; Practical Oncology and Radiotherapy, 2019 (In Press)
POLAND
GRADUATED STUDENT THESIS
2018
SZYMCZYK AGNIESZKA, B.Sc Thesis “Radiation synthesis of gold nanoparticles”
THAILAND
GRADUATED STUDENT THESIS
2016
THITIRAT RATTANAWONGWIBOON, PhD Thesis “Chemical and radiation induced synthesis of functional biopolymer-based nanoparticles for healthcare and medical applications”
EGYPT
GRADUATED STUDENT THESIS
2019
MOAMEN MOHAMED SOLIMAN, MSc Thesis “Nano Sized Delivery For Radiopharmaceuticals”
ITALY
GRADUATED STUDENT THESIS
2018
SELENIA BRUNCO, MSc Thesis “Sinetsi e caratterizzazione di nanogeli funzionalizzati per applicazioni biomediche”.
MEXICO
GRADUATED STUDENT THESIS
2019
MAYDELID TRUJILLO NOLASCO, PhD Thesis “Síntesis y evaluación de nanosistemas de liberación controlada basados en dendrimeros dirigidos al receptor de quimiocina-4”.
USA
full paper
2018
K. V. Katti, M. Khoobchandani, V. C. Thipe, A. Y. Al-Yasiri, K. K. Katti, S. K. Loyalka, T. M. Sakr, A. B. Lug?o. Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles. Journal of Radioanalytical and Nuclear Chemistry. 2018;318(3):1737-47.
USA
full paper
2015
Pasanphan W, Rattanawongwiboon T, Choofong S, Güven O, Katti KK. Irradiated chitosan nanoparticle as a water-based antioxidant and reducing agent for a green synthesis of gold nanoplatforms. Radiation Physics and Chemistry. 2015;106:360-70.
POLAND
full paper
2017
M. Matusiak, S. Kadlubowski, P. Ulanski, Radiation induced synthesis of poly(acrylic acid) nanogels, Radiation Physics and Chemistry, 142, 2018, 125-129, DOI:10.1016/j.radphyschem.2017.01.037,
POLAND
GRADUATED STUDENT THESIS
2017
WINCZEWSKI JEDRZEJ, B.Sc Thesis “Synthesis of gold nanoparticles stabilized with a-lipoic acid”
EGYPT
GRADUATED STUDENT THESIS
2019
MOHAMED MANSOUR AHMED SWIDAN, PhD Thesis “Development and biologicalevaluation of a novel delivery system for radiopharmaceuticals”
MEXICO
GRADUATED STUDENT THESIS
2016
ALEJANDRA ANCIRA CORTéZ, MSc Thesis “Preparación y caracterización denanopartículas de óxido de hierro funcionalizadas con ácido fólico/Rodamina a través de una reacción de entrecruzamiento tipo Carbodiimida”
BRAZIL
full paper
2016
Varca GHC, Kadlubowski S, Wolszczak M, Lug?o AB, Rosiak JM, Ulanski P. Synthesis of papain nanoparticles by electron beam irradiation: A pathway for controlled enzyme crosslinking. International Journal of Biological Macromolecules. 2016;92:654-9. doi: 10.1016/j.ijbiomac.2016.07.070.
IRAN
GRADUATED STUDENT THESIS
2019
MALIHE HAJIRAMEZANALI, PhD Thesis “ Preparation of Radiolabeled Bombesin Nanoparticles for In Vivo Gastrin-Releasing Peptide Receptor Imaging”
POLAND
GRADUATED STUDENT THESIS
2017
RARIVOSON ELONGE, M.Sc Thesis “Synthesising and studies of gold nanoparticles combined with biomass-derived compounds”
Iran
full paper
2016
29. Saeed Shanehsazzadeh, Cordula Grüttner, Hassan Yousefnia, Afsaneh Lahooti, Amir Gholami, Sahar Nosrati, Samaneh Zolghadri, Sayyed Hossein Mousavie Anijdan, Alireza Lotfabadi, Behrang Shiri Varnamkhasti, Fariba Johari Daha, Amir Reza Jalilian. Development of 177Lu-DTPA-SPIO conjugates for potential use as adual contrast SPECT/MRI imaging agent. Radiochim. Acta 2016;104:337–344.
MEXICO
full paper
2015
Orocio-Rodríguez, E., Ferro-Flores, G., Santos-Cuevas, C. L., Ramírez, F. D. M., Ocampo-García, B. E., Azorín-Vega, E., & Sánchez-García, F. M. (2015). Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging. Journal of Nanoscience and Nanotechnology,15(6), 4159-4169.
USA
GRADUATED STUDENT THESIS
2017
KIANDOKHT AMIRI, MSc Thesis “Resveratrol functionalized Gold Nanoparticles in Imaging and Therapy
POLAND
GRADUATED STUDENT THESIS
2018
ZIOMEK GABRIELA, B.Sc Thesis “Sonochemical synthesis of gold nanoparticles
MEXICO
full paper
2019
Ocampo-García, B., Gibbens-Bandala, B., Morales-Avila, E., Melendez-Alafort, L., Khoobchandani, M., Trujillo-Nolasco, M., & Katti, K. V. (2019). Dual-Targeted Therapy and Molecular Imaging with Radiolabeled Nanoparticles. In Biotechnology Products in Everyday Life (pp. 201-219). Springer, Cham.
MEXICO
full paper
2017
Ancira-Cortez A, Morales-Avila E, Ocampo-García BE, González-Romero C, Medina LA, López-Téllez G, et al. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials. 2017; 2017. https://www.hindawi.com/journals/jnm/2017/5184167/abs/
MEXICO
full paper
2017
Jaimes-Aguirre L, Morales-Avila E, Ocampo-García BE, Medina LA, López-Téllez G, Gibbens-Bandala BV, et al. Biodegradable poly (D, L-lactide-co-glycolide)/poly (L-?-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin. Materials Science and Engineering: C. 2017;76:743-51.
POLAND
full paper
2019
M. Matusiak, S. Kadlubowski, J.M. Rosiak, Nanogels synthesized by radiation-induced intramolecular crosslinking of water-soluble polymers, Radiation Physics and Chemistry, 2019, https://doi.org/10.1016/j.radphyschem.2018.12.019
MEXICO
GRADUATED STUDENT THESIS
2016
BRENDA VIANEY GIBBENS BANDALA, MSc. Thesis “Síntesis y caracterización de nanopartículas poliméricas de polimetilmetacrilato (PMMA) conjugadas con -RGD- para el transporte y liberación de paclitaxel”
ITALY
GRADUATED STUDENT THESIS
2017
LORENA ANNA DITTA, MSc Thesis “Doctorate in Innovation Technology” – XXX cycle. PhD Thesis: Ionizing radiation synthesis of multifunctional nanogels for biomedical applications”.
Argentina
full paper
2015
Achilli E, Casajus G, Siri M, Flores CY, Kadlubowski S, Alonso SDV, et al. Preparation of protein nanoparticle by dynamic aggregation and ionizing-induced crosslinking. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2015;486:161-71. doi: 10.1016/j.colsurfa.2015.09.047.
MEXICO
GRADUATED STUDENT THESIS
2016
LAURA JAIMES AGUIRRE, MSc Thesis “Obtención y caracterización de nanopartículas poliméricas de ácido poli(láctico-co-glicólico)/ácido poli(gama-glutámico) conjugadas con ácido fólico”
Argentina
full paper
2017
Flores CY, Achilli E, Grasselli M. Radiosynthesis of Gold/Albumin Core/shell Nanoparticles for Biomedical Applications. MRS Advances. 2017;2(49):2675-81. doi: 10.1557/adv.2017.527.
BRAZIL
full paper
2018
Santos JJ, Leal J, Dias LAP, Toma SH, Corio P, Genezini FA, et al. Bovine Serum Albumin Conjugated Gold-198 Nanoparticles as Model To Evaluate Damage Caused by Ionizing Radiation to Biomolecules. ACS Applied Nano Materials. 2018;1(9):5062-70. doi: 10.1021/acsanm.8b01174.
POLAND
full paper
2016
R.G. Queiroz, G.H.C. Varca, S. Kadlubowski, P. Ulanski, A.B. Lug?o, Radiation-synthesized protein-based drug carriers: Size-controlled BSA nanoparticles, International Journal of Biological Macromolecules 85, 2016, 82–91, DOI:10.1016/j.ijbiomac.2015.12.074
MEXICO
full paper
2016
Mendoza-Nava H, Ferro-Flores G, Ramírez FdM, Ocampo-García B, Santos-Cuevas C, Aranda-Lara L, et al. 177Lu-Dendrimer Conjugated to Folate and Bombesin with Gold Nanoparticles in the Dendritic Cavity: A Potential Theranostic Radiopharmaceutical. Journal of Nanomaterials. 2016,Volume 2016, Article ID 1039258, doi.org/10.1155/2016/1039258.
USA
GRADUATED STUDENT THESIS
2018
AMAL Y. AL-YASIRI PhD Thesis “Mangiferin functionalized Gold Nanoparticles in Imaging and Therapy”
ITALY
GRADUATED STUDENT THESIS
2018
BIONDO MARTINA, BSc Degree Thesis “Sistemi per il rilascio controllato di farmaci prodotti da polisaccaridi di origine marina”.
USA
full paper
2017
Katti KV. Al-Yasiri AY, Khoobchandani M, Cutler CS, Watkinson L, Carmack T, Smith CJ, et al. Mangiferin functionalized radioactive gold nanoparticles (MGF-(198)AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy. Dalton transactions (Cambridge, England : 2003). 2017;46(42):14561-71.
POLAND
full paper
2015
R. Czechowska-Biskup, B. Rokita, P. Ulanski, J.M. Rosiak, Preparation of gold nanoparticles stabilized by chitosan using irradiation and sonication methods, Progress on Chemistry and Application of Chitin and its Derivatives, 20, 2015, 18-33, DOI:10.15259/PCACD.20.02. http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.psjd-97a4273e-07ec-411d-9860-16acf006f6a3
full paper
2019
Hajiramezanali M, Atyabi F, Mosayebnia M, Akhlaghi M, Geramifar P, Jalilian AR, Mazidi SM, Yousefnia H, Shahhosseini S, Beiki D. 68Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation. Int J Nanomedicine. 2019 Apr 10;14:2591-2605. doi: 10.2147/IJN.S195223. eCollection 2019.
ITALY
GRADUATED STUDENT THESIS
2018
MOHAMED ABOZEID, PhD Thesis “Imaging and Radioimmunotheraphy of Pancreatic Cancer”
MEXICO
AWARDS
2014
Awarded Thesis. 2014, ROSALBA MONSERRAT MIRANDA OLVERA, B.Sc. Thesis (Sistema multivalente para la terapia de linfomas no-Hodking basado en Anti CD-20 conjugado a nanopartículas de oro).
ITALY
GRADUATED STUDENT THESIS
2015
FEDERICO ANTONINI, MSc Thesis “Radiation Synthesis and charcterisation of PVP based nanogels (Research activity carried out in POLAND-Lodz”
Argentina
Research paper
2015
E. Achilli, G. Casajus, M. Siri, C. Flores, S. Kadlubowski, S.del V. Alonso, Mariano Grasselli. Preparation of protein nanoparticle by dynamic aggregation and ionizing induced crosslinking, Colloids and Surfaces A: Physicochemical and Engineering Aspects. (2015). 10.1016/j.colsurfa.2015.09.047
BRAZIL
full paper
2016
Varca GHC, Queiroz RG, Lug?o AB. Irradiation as an alternative route for protein crosslinking: Cosolvent free BSA nanoparticles. Radiation Physics and Chemistry. 2016;124:111-5. doi: 10.1016/j.radphyschem.2016.01.021.
Thailand
full paper
2016
WONGKRONSAK, S., TANGTHONG, T., PASANPHAN, W., “Electron beam induced water-soluble silk fibroin nanoparticles as a natural antioxidant and reducing agent for a green synthesis of gold nanocolloid”, Radiat. Phys. Chem. 118 (2016) 27–34.
BRAZIL
GRADUATED STUDENT THESIS
2019
ARYEL HEITOR FERREIRA, PhD ThesisEvaluation of protein-based nanoparticles as potentials diagnostic agents.
POLAND
GRADUATED STUDENT THESIS
2019
MATUSIAK MALGORZATA, Ph.D Thesis “Radiation synthesis of polymer nanogels and their potential application as a carrier of bioactive substances”
BRAZIL
GRADUATED STUDENT THESIS
2019
JORGE GABRIEL S. BATISTA, PhD Thesis Synthesis, characterization and functionalization of gold nanoparticles for application in cancer diagnosis and therapy
ITALY
full paper
2017
Dispenza C, Sabatino MA, Ajovalasit A, Ditta LA, Ragusa M, Purrello M, et al. Nanogel-antimiR-31 conjugates affect colon cancer cells behaviour. RSC Advances. 2017;7(82):52039-47. doi: 10.1039/C7RA09797B
Iran
PhD thesis
2015
Radiolabelled Chitosan Nanocarriers as promising agents for Imaging &Therapy of cancer " Esmaeel Molarazi , (2012-2015)
PAKISTAN
GRADUATED STUDENT THESIS
2020 (PLANNED)
RIZWANA ZAHOOR, PhD Thesis “Development of Multifunctional Radiolabelled Biomolecules for Cancer Diagnosis and Therapy”.
MEXICO
full paper
2019
Synthesis and Biodistribution Study of Biocompatible 198Au Nanoparticles by use of Arabinoxylan as Reducing and Stabilizing Agent, ACCEPTED in “Biological Trace Element Research”, manuscript #: BTER-D-18-01156
PAKISTAN
GRADUATED STUDENT THESIS
2017
FOZIA IRUM, PhD Thesis “Studying Synthesis and Biodistribution of Gold-198 Nanoparticles by developing Carbohydrate Polymers as Reducing Agents”.
Argentina
full paper
2019
Flores CY, H LJM, Achilli E, Schinca DC, Grasselli M. Plasmon properties of multilayer albumin/gold hybrid nanoparticles. Materials Research Express. 2019;6(5):55005. doi: 10.1088/2053-1591/aaedd8.
IRAN
GRADUATED STUDENT THESIS
2016
ESMAIL MOLLARAZI, PhD Thesis “Development of Folate ConjugatedC nanoparticles for Theranostic Applications”
Argentina
full paper
2018
Flores CY, Achilli E, Grasselli M. Radiation-induced preparation of core/shell gold/albumin nanoparticles. Radiation Physics and Chemistry. 2018;142:60-4. doi: 10.1016/j.radphyschem.2017.02.030.
USA
full paper
2018
Santos JJ, Leal J, Dias LAP, Toma SH, Corio P, Genezini FA, et al. Bovine Serum Albumin Conjugated Gold-198 Nanoparticles as Model To Evaluate Damage Caused by Ionizing Radiation to Biomolecules. ACS Applied Nano Materials. 2018;1(9):5062-70. doi: 10.1021/acsanm.8b01174.
BRAZIL
full paper
2018
Fazolin GN, Varca GHC, Kadlubowski S, Sowinski S, Lug?o AB. The effects of radiation and experimental conditions over papain nanoparticle formation: Towards a new generation synthesis. Radiation Physics and Chemistry. 2018. doi: 10.1016/j.radphyschem.2018.08.033.
BRAZIL
full paper
2018
Freitas de Freitas L, Varca GHC, Dos Santos Batista JG, Benévolo Lug?o A. An Overview of the Synthesis of Gold Nanoparticles Using Radiation Technologies. Nanomaterials (Basel, Switzerland). 2018;8(11):939. doi: 10.3390/nano8110939.
Thailand
full paper
2015
PASANPHAN, W., RATTANAWONGWIBOON, T., CHOOFONG, S., GUVEN, O., KATTI, K., “Irradiated chitosan nanoparticle as a water-based antioxidant and reducing agent for a green synthesis of gold nanoplatforms”, Radiat. Phys. Chem. 106 (2015) 360–370.
MEXICO
full paper
2017
Gibbens-Bandala BV, Ocampo-Garcia BE, Ferro-Flores G, Morales-Avila E, Ancira-Cortez A, Jaimes-Aguirre L. Multimeric System of RGD-Grafted PMMA-Nanoparticles as a Targeted Drug- Delivery System for Paclitaxel. Curr Pharm Des. 2017;23(23):3415-22. Epub 2017/04/14. doi: 10.2174/1381612823666170407143525. PubMed PMID: 28403791. https://www.ncbi.nlm.nih.gov/pubmed/28403791
ARGENTINA
GRADUATED STUDENT THESIS
2019
ESTEFANIA ACHILLI “Dise?o de nanopartículas proteicas con reconocimiento molecular mediante entrecruzamiento radioinducido”
BRAZIL
GRADUATED STUDENT THESIS
2019
GABRIELA N. FAZOLIN, MSc Thesis “Radiation-induced synthesis of bioactive papain-based nanocarriers for radiopharmaceuticals delivery”
MEXICO
GRADUATED STUDENT THESIS
2019
BRENDA VIANEY GIBBENS BANDALA, PhD Thesis “Preparación, caracterización y evaluación in vitro e in vivo de dos radiofármacos terapéuticos de liberación controlada basados en nanosistemas poliméricos”
MEXICO
full paper
2017
Morales-Avila, E., Ferro-Flores, G., Ocampo-García, B. E., López-Téllez, G., López-Ortega, J., Rogel-Ayala, D. G., & Sánchez-Padilla, D. (2017). Antibacterial efficacy of gold and silver nanoparticles functionalized with the ubiquicidin (29–41) antimicrobial peptide. Journal of Nanomaterials, 2017.
Thailand
full paper
2018
RATTANAWONGWIBOON, T., GHAFFARLOU, M., SUTEKIN, S.D., PASANPHAN, W., GUVEN, O., “Preparation of multifunctional poly(acrylic acid)-poly(ethylene oxide) nanogels from their interpolymer complexes by radiation-induced intramolecular crosslinking”, Colloid Polym. Sci., 296 (2018) 1599–1608.
ITALY
GRADUATED STUDENT THESIS
2015
EMILIA BUFFA, MSc Thesis “Synthesis and modification of nanogels for application in radiotherapy (Research activity carried out in POLAND-Lodz Erasmus exchange with POLAND-Lodz)”
Argentina
full paper
2017
Siri M, Achilli E, Grasselli M, Alonso SV. Albumin nanocarriers, ?- irradiated crosslinked, combined with therapeutic drugs for cancer therapy. Current pharmaceutical design. 2017;23(35):5272-82. doi: 10.2174/1381612823666170615105909
Iran
full paper
2015
51. Esmail Mollarazi, Amir R. Jalilian, Fariba Johari-daha, Fatemeh Atyabi, Development of 153Sm-folate-PEI conjugated chitosan nanoparticles for targeted therapy purposes, J. Label Compd. Radiopharm 2015, 58 327–335.
Egypt
presentation
2015
"Radiosynthesis and Quality Control of Nanosized resveratrol-Au-198" T. M. Sakr, K.K. Katti, L. Watkinson, T. Carmack, C. J. Smith, C. Cutler, K. V. Katti. Journal of Labelled Compound and Radiopharmaceuticals, (ISRS 2015 Poster), 58, S403 (2015).
USA
GRADUATED STUDENT THESIS
2015
RAJESH KULKARNI, MSc Thesis “Gold Nanoparticles in Radiosensitization for Imaging and Therapy”
EGYPT
GRADUATED STUDENT THESIS
2019
BASMA MOHAMED SAIED ESSA, PhD Thesis “Nano-sized Particles as New Radioisotopes Carriers for Medical Applications”
MEXICO
full paper
2017
Jaimes-Aguirre, L., Morales-Avila, E., Ocampo-García, B. E., Medina, L. A., López-Téllez, G., Gibbens-Bandala, B. V., & Izquierdo-Sánchez, V. (2017). Biodegradable poly (D, L-lactide-co-glycolide)/poly (L-?-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin. Materials Science and Engineering: C, 76, 743-751.
ITALY
GRADUATED STUDENT THESIS
2015
MARILENA SPERA, BSc Degree Thesis “Nanoparticelle d’oro: sintesi, proprietà ed applicazioni emergenti”.
ITALY
GRADUATED STUDENT THESIS
2016
CHIARA CARBONE, MSc Thesis “Synthesis and modification of nanogels for biomedical applications (Research activity carried out in POLAND-Lodz)”
Argentina
full paper
2016
Siri M, Grasselli M, Alonso S del V. Albumin-based nanoparticle trehalose lyophilisation stress-down to preserve structure/function and enhanced binding. Journal of pharmaceutical and biomedical analysis. 2016;126:66-74. Epub 2016/05/14. doi: 10.1016/j.jpba.2016.04.037. PubMed PMID: 27174378.
ITALY
full paper
2019
Ditta LA, Dahlgren B, Sabatino MA, Dispenza C, Jonsson M. The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels. European Polymer Journal. 2019;114:164-75. doi: 10.1016/j.eurpolymj.2019.02.020.
USA
PATENTS
Inventors: Kattesh K. Katti, Raghuraman Kannan, Kavita K. Katti, Nripen Chanda, Ravi Shukla. Title: Soy or lentil stabilized gold nanoparticles and method for making same. Patent number: 8586096
ITALY
GRADUATED STUDENT THESIS
2019
ERMINIA MUSCOLINO, MSc Thesis “Sintesi di nanogeli funzionalizzati con cisteina per l’incorporazione di radionuclidi di interesse terapeutico e diagnostico”
Iran
2015
Esmail Mollarazi, Amir R. Jalilian, Fariba Johari-daha, Fatemeh Atyabi, Development of 153Sm-folatepolyethyleneimine-conjugated chitosan nanoparticles for targeted therapy, J. Label Compd. Radiopharm 2015, 58 327–335 Copyright ? 2015 John Wiley & Sons, Ltd
THAILAND
AWARDS
2016
Best Poster Presentation Award: TANGTHONG, T., PASANPHAN, W, “DOTA-BBN peptide conjugated water-soluble chitosan nanoparticles for a green synthesis of gold nanoplatform as a potential targeting radiopharmaceuticals”, Pure and Applied Chemistry International Conference (PACCON2016), Thailand: One hundred year of advancement chemistry, Bangkok, Thailand.
THAILAND
GRADUATED STUDENT THESIS
2019
THEERANAN TANGTHONG, PhD Thesis “DOTA-bombesin (DOTA-BBN) peptide conjugated biopolymers and gold nanoparticles synthesis as radiopharmaceutical nanocarrier and therapeutic agents”
BRAZIL
GRADUATED STUDENT THESIS
2019
ADRIANA K. CAVALCANTE, PhD Thesis “Acute toxicity study of gold nanoparticles in Danio rerio”
USA
full paper
2016
Geraldes AN, da Silva AA, Leal J, Estrada-Villegas GM, Lincopan N, Katti KV, et al. Green nanotechnology from plant extracts: synthesis and characterization of gold nanoparticles. Advances in Nanoparticles. 2016;5(03):176.
BRAZIL
PATENTS
Inventors: Katti, K. V.; Katti, K. K.; Lug?o, A. B.; Varca, G. H. C.; Marques, F. L. N.; Ferreira, A.H. Title: Imaging agent from SPECT-probe-nanoparticle conjugates. Patent number: USPTO No 0800528.0143
Argentina
Research paper
2015
Albumin-based nanoparticle trehalose lyophilisation stress-down to preserve structure/function. M.Siri, M. Grasselli, S. del V. Alonso. Journal of Pharmaceutical and Biomedical Analysis. Submitted Feb. 22nd 2016. JPBA-D-16-00302. Accepted.
Mexico
Research paper
2015
Orocio-Rodríguez, E., Ferro-Flores, G., Santos-Cuevas, C. L., Ramírez, F. D. M., Ocampo-García, B. E., Azorín-Vega, E., & Sánchez-García, F. M. (2015). Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging. Journal of Nanoscience and Nanotechnology,15(6), 4159-4169.
ARGENTINA
GRADUATED STUDENT THESIS
2017
MACARENA SIRI, PhD Thesis “Estudio de Nanopartículas Proteicas y su posible aplicación como vectores de drogas antitumorales”
BRAZIL
GRADUATED STUDENT THESIS
2019
GUSTAVO H. C. VARCA, PhD Thesis “Development of a nanostructured hydrogel based on polyvinylpyrrolidone containing papain complexed cyclodextrin”
Mexico
Presentation
2015
Ocampo-García B.E., Ferro-Flores G., Orocio- Ramírez F. de M., Santos-Cuevas C.L., Azorín-Vega E., Isaac-Olivé K. Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging, 21th International Symposium on Radiopharmaceutical Science, University of Missouri, Missouri, USA. May 26-31, 2015
EGYPT
full paper
2018
Sakr TM, Khowessah O, Motaleb M, El-Bary AA, El-Kolaly M, Swidan MM. I-131 doping of silver nanoparticles platform for tumor theranosis guided drug delivery. European Journal of Pharmaceutical Sciences. 2018;122:239-45.
THAILAND
GRADUATED STUDENT THESIS
2015
SORAYA WONGKRONGSAK, MSc Thesis "Electron beam induced-silk fibroin nanoparticles and their conjugation with DOTA-bombesin for green synthesis of gold nanoparticles”
POLAND
full paper
2016
R.G. Queiroz, G.H.C. Varca, S. Kadlubowski, P. Ulanski, A.B. Lug?o, Radiation-synthesized protein-based drug carriers: Size-controlled BSA nanoparticles, International Journal of Biological Macromolecules 85, 2016, 82–91, DOI:10.1016/j.ijbiomac.2015.12.074
MEXICO
GRADUATED STUDENT THESIS
2018
ROSA MAYDELID TRUJILLO NOLASCO, MSc. Thesis “Preparación y caracterización de nanopartículas de ácido poli(láctico-co-glicólico) PLGA modificadas con ácido hialurónico y radiomarcadas con 177Lu para la liberación controlada de metotrexato”
USA
full paper
2014
Chanda N, Upendran A, Boote EJ, Zambre A, Axiak S, Selting K, et al. Gold nanoparticle based X-ray contrast agent for tumor imaging in mice and dog: a potential nanoplatform for computer tomography theranostics. Journal of biomedical nanotechnology. 2014;10(3):383-92.
ITALY
GRADUATED STUDENT THESIS
2016
VALERIA D’ANGELO, MSc Thesis “Sintesi e modifica di nanogels per applicazioni radiofarmaceutiche”
THAILAND
GRADUATED STUDENT THESIS
2015
THEERANAN TANGTHONG, MSc Thesis "DOTA-BBN peptide conjugated water-soluble chitosan nanoparticles for a green synthesis of gold nanoplatform as a potential targeting radiopharmaceuticals”
ITALY
GRADUATED STUDENT THESIS
2017
LORENA ANNA DITTA, PhD Thesis “Ionizing radiation synthesis of multifunctional nanogels for biomedical applications”
POLAND
GRADUATED STUDENT THESIS
2014
PASZKOWSKA ANNA, BSc Thesis “Stabilization of metals nanoparticles generated by irradiation using polymers”
EGYPT
full paper
2019
Swidan MM, Khowessah OM, El-Motaleb MA, El-Bary AA, El-Kolaly MT, Sakr TM. Iron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99 m radionuclide: a potential molecular imaging probe for tumor diagnosis. DARU Journal of Pharmaceutical Sciences. 2019:1-10.
POLAND
full paper
2014
S. Kadlubowski, Radiation-induced synthesis of nanogels based on poly(N-vinyl-2-pyrrolidone)—A review, Radiation Physics and Chemistry, 102, 2014, 29-39, https://doi.org/10.1016/j.radphyschem.2014.04.016