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          Short Course Versus Standard Course Radiotherapy, in Elderly and/or Fragile Patients with Glioblastoma Multiform (GBM)

          Closed for proposals

          Project Type

          Coordinated Research Project

          Project Code

          E33033

          CRP

          1521

          Approved Date

          11 December 2008

          Status

          Closed

          Start Date

          4 February 2009

          Expected End Date

          4 February 2015

          Completed Date

          27 March 2015

          Description

          Brain tumours represent less than 1.5% of all cancer. Glioblastoma multiforme is the most frequent malignant glioma occuring in adults. The treatment of glioblastoma multiforme is an important issue in radiation oncology worldwide, especially in developing countries. By optimizing fractionation in palliative setting of these tumors, it is expected that Member States will benefit from the rational use of the existing equipment and staff levels, decreasing costs, and improving patients’ access to radiotherapy, yet providing effecrtive treatment for such patients. This CRP continues Agency’s research efforts that have improved clinical practice in palliative radiotherapy in other settings.

          Objectives

          This study assessed the effect of a one-week radiotherapy regimen in comparison with a three-week radiotherapy regimen on the overall survival of elderly and/or frail patients with glioblastoma multiforme (GBM).

          Specific objectives

          1. Overall survival was the primary objective for this study.

          Secondary objectives included comparison of health-related quality of life (HR QoL) between the two treatment arms.

          Impact

          Short course RT protocol for treatment of GBM in elderly and/or frail patients will help to deliver palliative care with efficient use of resources in all Member States.

          Relevance

          Research in palliative RT for GBM is relevant for all MSs.

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