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          Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry

          Closed for proposals

          Project Type

          Coordinated Research Project

          Project Code

          E21007

          CRP

          1528

          Approved Date

          30 October 2008

          Status

          Closed

          Start Date

          11 June 2009

          Expected End Date

          11 June 2014

          Completed Date

          15 July 2015

          Description

          Nuclear Medicine instruments have the potential to provide quantitative information and its distribution with time. This information provides the basis for internal dosimetry and is needed to properly optimize the use of any radiopharmaceutical. Patient specific dosimetry is often a legal obligation when administering radiopharmaceuticals for therapy. There are, however, no harmonized protocols or guidelines for acquiring quantitative information from Nuclear Medicine instruments. Nor are there documents that address the possibilities and limitations of these instruments for quantitative information. This CRP aims at addressing this gap.

          Objectives

          The overall objective of this project is to assist Member States in accurately determining radionuclide distributions for diagnostic and therapeutic nuclear medicine.

          Specific objectives

          Assess the need for standardisation and harmonisation of quantitative nuclear medicine

          Assess the need for training in the field of absolute quantitation and internal dosimetry

          Determine the achievable accuracy of absolute activity quantitation for different nuclear medicine methodologies
          in a range of sites with various levels of available resources

          Develop and test quantitative imaging methods in nuclear medicine practice

          Impact

          1) The publication on Quantitative Nuclear Medicine Imaging (IAEA Human Health Reports No. 9) has been very popular in the Member States.
          2) Through this CRP research networks were developed. The collaboration of the participants continues even after the end of the CRP.
          3) The journal paper with the results of the Ba-133 intercomparison has received a lot of interest in the nuclear medicine medical physics community.

          Relevance

          The topic of the CRP is of continuous relevance with the objectives of the project 2.2.4.3, as it provides guidance to Member States to apply advanced and accurate dosimetry practices in therapeutic nuclear medicine.

          CRP Publications

          Type

          SNMMI Annual Meeting, St. Louis, USA, June 7-11, 2014

          Year

          2014

          Publication URL

          http://jnumedmtg.snmjournals.org/cgi/content/short/55/1_MeetingAbstracts/55

          Description

          International intercomparison of absolute quantification in nuclear medicine

          Country/Organization

          Society of Nuclear Medicine

          Type

          Bangladesh Cancer Congress, Dhaka, Bangladesh, August 22-23, 2014

          Year

          2014

          Description

          Image Based Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study

          Country/Organization

          Oncology Club, Bangladesh

          Type

          Zeitschrift für Medizinische Physik

          Year

          2016

          Publication URL

          http://www.sciencedirect.com/science/article/pii/S0939388916300034

          Description

          International multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification

          Country/Organization

          German and Austrian Society of Medical Physics and the Swiss Society of Radiobiology and Medical Physics

          Type

          XIII Congreso de ALASBIMN, 28 September – 1 October, 2011

          Year

          2011

          Description

          Evaluación dosimétrica pre-terapéutica de 177Lu-DOTA-TATE en pacientes con tumores neuroendócrinos en Uruguay

          Country/Organization

          Asociación Latinoamericana de Sociedades de Biología y Medicina Nuclear

          Type

          Bangladesh Journal of Nuclear Medicine Vol. 17, No. 1, January 2014, p. 80

          Year

          2014

          Description

          Ba-133 Phantom study to evaluate image based patient specific dosimetry in radionuclide therapy

          Country/Organization

          Society of Nuclear Medicine, Bangladesh

          Type

          13th IRPA International Congress, Glasgow, May 14-18, 2012

          Year

          2012

          Publication URL

          http://www.irpa.net/members/TS7b.5.pdf

          Description

          Optimization of a routine method for bone marrow dose estimation in 177Lu-EDTMP therapy: Experience in Uruguay

          Country/Organization

          International Radiation Protection Association

          Type

          Human Health Report

          Year

          In the editorial process

          Description

          Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods

          Country/Organization

          IAEA

          Type

          Radiation protection dosimetry, 2010, 141.1: 50-55

          Year

          2010

          Publication URL

          https://rpd.oxfordjournals.org/content/141/1/50.full

          Description

          The determination of patient dose from 18F-FDG PET/CT examination

          Country/Organization

          Thailand

          Type

          26th EANM Annual Congress, Lyon, October 19-23, 2013

          Year

          2013

          Description

          Effect of calibration source geometry on shape on absolute activity quantification in SPECT

          Country/Organization

          European Association of Nuclear Medicine

          Type

          8th International Congress of the Croatian Society of Nuclear Medicine, ?ibenik, May 9–12, 2014

          Year

          2014

          Description

          Activity Quantification of 133Ba Sources In Water Phantom

          Country/Organization

          Croatian Society of Nuclear Medicine

          Type

          Bangladesh Journal of Nuclear Medicine, Vol. 17, No. 2, July 2014, p. 134:137

          Year

          2014

          Description

          Quantification of Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study

          Country/Organization

          Society of Nuclear Medicine, Bangladesh

          Type

          Journal of research of the National Institute of Standards and Technology

          Year

          2013

          Publication URL

          http://nvlpubs.nist.gov/nistpubs/jres/118/jres.118.017.pdf

          Description

          Calibration of Traceable Solid Mock 131I Phantoms Used in an International SPECT Image Quantification Comparison

          Country/Organization

          National Institute of Standards and Technology, Gaithersburg, USA

          Type

          4th International Conference on Radiopharmaceutical Therapy, Ho Chi Minh City, Vietnam, November 28 – December 2, 2011

          Year

          2011

          Description

          Quantitative Study of the Different Protocols Analysis for Excess Radiation Absorbed Doses from Radioiodine Treatment of Hyperthyroidism in Bangladesh

          Country/Organization

          Bangladesh

          Type

          Bangladesh Journal of Nuclear Medicine, Vol. 16, No. 1, January 2013, p. 41-44

          Year

          2013

          Description

          Quantification of Thyroid Activity Using Conjugate View Method with Gamma Camera Images

          Country/Organization

          Society of Nuclear Medicine, Bangladesh

          Type

          Phys Med Biol, 2015; 60:1325-1337

          Year

          2015

          Publication URL

          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437762/

          Description

          Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source

          Country/Organization

          USA

          Type

          Journal of Nuclear Medicine, 2013, 54.supplement 2: 2061-2061

          Year

          2013

          Publication URL

          http://jnm.snmjournals.org/content/54/supplement_2/2061

          Description

          Factors affecting repeatability of activity quantification in SPECT/CT

          Country/Organization

          Society of Nuclear Medicine

          Type

          28th EANM Annual Congress, Hamburg, October 10-14, 2015

          Year

          2015

          Description

          International Multicentre Evaluation of Absolute Quantification in Planar and SPECT Imaging

          Country/Organization

          European Association of Nuclear Medicine

          Type

          ARCCNM/KSNM International Symposium, October 24-27, 2012, Seoul, Korea

          Year

          2012

          Description

          Quantification of Thyroid Uptake with Gamma Camera Images

          Country/Organization

          Asia Oceania Federation of Nuclear Medicine and Biology and Korean Society of Nuclear Medicine

          Type

          Bangladesh Journal of Nuclear Medicine, Vol. 15, No. 1, January 2012, p. 22-25

          Year

          2012

          Description

          Quantitative Study of Hyperthyroid Patient by Employing Different Protocols at the Institute of Nuclear Medicine and Ultrasound (INMU)

          Country/Organization

          Society of Nuclear Medicine, Bangladesh

          Type

          2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)

          Year

          2013

          Description

          Stability of activity quantification in SPECT/CT

          Country/Organization

          Society of Nuclear Medicine

          Type

          XLII Congresso Brasileiro de Radiologia & XXVII Congresso Brasileiro de Medicina Nuclear, Curitiba, October 10-12, 2013

          Year

          2013

          Description

          Intercomparación de la cuantificación de imágenes en centros de Medicina Nuclear de América Latina. Resultados preliminaries

          Country/Organization

          Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, Brazil

          Type

          2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)

          Year

          2013

          Description

          Accuracy and repeatability of quantitative 131-I SPECT: phantom design and benchmark results

          Country/Organization

          Society of Nuclear Medicine

          Type

          13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics, Singapore, December 12-14, 2013

          Year

          2013

          Description

          Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry: IAEA Coordinated Research Project

          Country/Organization

          Asia-Oceania Congress of Medical Physics & South-East Asian Congress of Medical Physics

          Stay in touch

          Newsletter

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