Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry
Closed for Proposals
Project Type
Coordinated Research ProjectProject Code
E21007
CRP
1528
Approved Date
30 October 2008Project Status
ClosedStart Date
11 June 2009Expected End Date
11 June 2014Completed Date
15 July 2015Description
Nuclear Medicine instruments have the potential to provide quantitative information and its distribution with time. This information provides the basis for internal dosimetry and is needed to properly optimize the use of any radiopharmaceutical. Patient specific dosimetry is often a legal obligation when administering radiopharmaceuticals for therapy. There are, however, no harmonized protocols or guidelines for acquiring quantitative information from Nuclear Medicine instruments. Nor are there documents that address the possibilities and limitations of these instruments for quantitative information. This CRP aims at addressing this gap.
Objectives
The overall objective of this project is to assist Member States in accurately determining radionuclide distributions for diagnostic and therapeutic nuclear medicine.
Specific Objectives
Assess the need for standardisation and harmonisation of quantitative nuclear medicine
Assess the need for training in the field of absolute quantitation and internal dosimetry
Determine the achievable accuracy of absolute activity quantitation for different nuclear medicine methodologies
in a range of sites with various levels of available resources
Develop and test quantitative imaging methods in nuclear medicine practice
Impact
1) The publication on Quantitative Nuclear Medicine Imaging (IAEA Human Health Reports No. 9) has been very popular in the Member States.
2) Through this CRP research networks were developed. The collaboration of the participants continues even after the end of the CRP.
3) The journal paper with the results of the Ba-133 intercomparison has received a lot of interest in the nuclear medicine medical physics community.
Relevance
The topic of the CRP is of continuous relevance with the objectives of the project 2.2.4.3, as it provides guidance to Member States to apply advanced and accurate dosimetry practices in therapeutic nuclear medicine.
CRP Publications
Asia Oceania Federation of Nuclear Medicine and Biology and Korean Society of Nuclear Medicine
ARCCNM/KSNM International Symposium, October 24-27, 2012, Seoul, Korea
2012
Quantification of Thyroid Uptake with Gamma Camera Images
Society of Nuclear Medicine, Bangladesh
Bangladesh Journal of Nuclear Medicine Vol. 17, No. 1, January 2014, p. 80
2014
Ba-133 Phantom study to evaluate image based patient specific dosimetry in radionuclide therapy
Society of Nuclear Medicine, Bangladesh
Bangladesh Journal of Nuclear Medicine, Vol. 17, No. 2, July 2014, p. 134:137
2014
Quantification of Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study
Asia-Oceania Congress of Medical Physics & South-East Asian Congress of Medical Physics
13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics, Singapore, December 12-14, 2013
2013
Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry: IAEA Coordinated Research Project
Society of Nuclear Medicine, Bangladesh
Bangladesh Journal of Nuclear Medicine, Vol. 15, No. 1, January 2012, p. 22-25
2012
Quantitative Study of Hyperthyroid Patient by Employing Different Protocols at the Institute of Nuclear Medicine and Ultrasound (INMU)
IAEA
Human Health Report
In the editorial process
Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods
Asociación Latinoamericana de Sociedades de Biología y Medicina Nuclear
XIII Congreso de ALASBIMN, 28 September – 1 October, 2011
2011
Evaluación dosimétrica pre-terapéutica de 177Lu-DOTA-TATE en pacientes con tumores neuroendócrinos en Uruguay
USA
Phys Med Biol, 2015; 60:1325-1337
2015
Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source
Society of Nuclear Medicine
2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)
2013
Accuracy and repeatability of quantitative 131-I SPECT: phantom design and benchmark results
Society of Nuclear Medicine
2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)
2013
Stability of activity quantification in SPECT/CT
Croatian Society of Nuclear Medicine
8th International Congress of the Croatian Society of Nuclear Medicine, ?ibenik, May 9–12, 2014
2014
Activity Quantification of 133Ba Sources In Water Phantom
German and Austrian Society of Medical Physics and the Swiss Society of Radiobiology and Medical Physics
Zeitschrift für Medizinische Physik
2016
International multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification
Society of Nuclear Medicine
SNMMI Annual Meeting, St. Louis, USA, June 7-11, 2014
2014
International intercomparison of absolute quantification in nuclear medicine
Society of Nuclear Medicine
Journal of Nuclear Medicine, 2013, 54.supplement 2: 2061-2061
2013
Factors affecting repeatability of activity quantification in SPECT/CT
Bangladesh
4th International Conference on Radiopharmaceutical Therapy, Ho Chi Minh City, Vietnam, November 28 – December 2, 2011
2011
Quantitative Study of the Different Protocols Analysis for Excess Radiation Absorbed Doses from Radioiodine Treatment of Hyperthyroidism in Bangladesh
European Association of Nuclear Medicine
28th EANM Annual Congress, Hamburg, October 10-14, 2015
2015
International Multicentre Evaluation of Absolute Quantification in Planar and SPECT Imaging
Society of Nuclear Medicine, Bangladesh
Bangladesh Journal of Nuclear Medicine, Vol. 16, No. 1, January 2013, p. 41-44
2013
Quantification of Thyroid Activity Using Conjugate View Method with Gamma Camera Images
International Radiation Protection Association
13th IRPA International Congress, Glasgow, May 14-18, 2012
2012
Optimization of a routine method for bone marrow dose estimation in 177Lu-EDTMP therapy: Experience in Uruguay
Oncology Club, Bangladesh
Bangladesh Cancer Congress, Dhaka, Bangladesh, August 22-23, 2014
2014
Image Based Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, Brazil
XLII Congresso Brasileiro de Radiologia & XXVII Congresso Brasileiro de Medicina Nuclear, Curitiba, October 10-12, 2013
2013
Intercomparación de la cuantificación de imágenes en centros de Medicina Nuclear de América Latina. Resultados preliminaries
European Association of Nuclear Medicine
26th EANM Annual Congress, Lyon, October 19-23, 2013
2013
Effect of calibration source geometry on shape on absolute activity quantification in SPECT
National Institute of Standards and Technology, Gaithersburg, USA
Journal of research of the National Institute of Standards and Technology
2013
Calibration of Traceable Solid Mock 131I Phantoms Used in an International SPECT Image Quantification Comparison
Thailand
Radiation protection dosimetry, 2010, 141.1: 50-55
2010
The determination of patient dose from 18F-FDG PET/CT examination