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          Longitudinal Monitoring of Complicated Osteomyelitis by SPECT/CT

          Closed for proposals

          Project Type

          Coordinated Research Project

          Project Code

          E13035

          CRP

          1495

          Approved Date

          29 May 2008

          Status

          Closed

          Start Date

          30 October 2008

          Expected End Date

          31 October 2011

          Completed Date

          28 January 2013

          Description

          The key fact remains that the diagnosis and management of complicated osteomyelitis still represents a challenge for physicians. On a global scale especially, posttraumatic osteomyelitis, endo-prosthesis infection (all prosthetic materials, also nails and plates) and diabetic foot, involve high social and economic cost. Optimal treatment in many countries is often not granted so the infection rate is relatively high. Many of these patients require long term clinical management and treatment options are less than objective. The novel technology of SPECT/CT is expected to improve the diagnosis and management of these patients. There is a need to assess the importance of nuclear medicine techniques in the long term follow-up of complicated osteomyelitis.
          This CRP will seek to assess the role of hybrid or fusion SPECT/CT imaging in diagnostic work-up and management of patients with complicated osteomyelitis. The success of this will strengthen the referral for this traditional type of nuclear medicine service. The CRP will provide suitable guidelines to improve treatment outcomes of chronic, complicated osteomyelitis and therefore impact on social and economic benefit for many communities.

          Objectives

          To establish effective use of molecular imaging using hybrid system (SPECT/CT, PET/CT etc.) in a selected number of developing Member States in the management of disease through Agency support.

          Specific objectives

          Clinically to assess the role of hybrid or fusion SPECT/CT imaging in diagnostic work-up and management of patients with complicated bone infections of profound social and economically significant (i.e.Post-traumatic osteomyelitis, Diabetic foot and Endoprosthesis infection (all prosthetic materials, also nails and plates)

          To define the incremental value of combined functional and anatomical imaging by SPECT/CT in the assessment of bone infection over scintigraphy alone.

          Impact

          The CRP provided adequate platform for cooperative research among member states, which emphasized the growing importance of hybrid imaging in the management of certain disease conditions, like bone infection.

          The addition of SPECT/CT to planar infection imaging was of value for the diagnosis of bony infection in about 29% of the patients of the current study by defining the precise location of infection to bone and/or soft tissues and by excluding bone involvement adjacent to soft tissue infection. It also helped in defining the extent of osteomyelitis in 22% of the patients found to have osteomyelitis.

          Relevance

          The findings of this study suggest that SPECT/CT is of significant value in localization the infection and defining the extent of osteomyelitis in patients with complicated OM, which could help in overall management of such patients

          CRP Publications

          Type

          JOURNAL

          Year

          2011

          Publication URL

          http://jnumedmtg.snmjournals.org/cgi/content/meeting_abstract/52/1_MeetingAbstra…

          Country/Organization

          USA

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