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          Integrated Imaging (SPECT/CT; PET/CT; MRI) in Infection/Inflammation Spine Pathology

          Closed for Proposals

          Project Type

          Coordinated Research Project

          Project Code

          E13040

          CRP

          1990

          Approved Date

          13/09/2013

          Project Status

          Closed

          Start Date

          13/09/2013

          Expected End Date

          31/01/2018

          Completed Date

          03/05/2019

          Description

          Summary of the Background/Research Problem?? The prevalence of back pain has increased worldwide.? Low back pain is now the 6th most common cause for global disability-adjusted life years. ? There is likely an increase in spinal surgery in the future. ? The most serious complication after spinal surgery is spinal infection.? There remains uncertainty about the imaging modality of choice in the diagnosis of post-operative spinal infection.? There is therefore a clear need for research on imaging modality of choice in the diagnosis of post-operative spinal infection.? There has been a worldwide increase in hybrid imaging (SPECT/CT, PET/CT) and MRI.? Taken into account the above mentioned points, with and increasing prevalence of back pain in low-middle income countries, ???is likely going to translate -in the near future- into an increased incidence of spinal surgery, and the associated complications ?? of it, of which infection at the surgical site is the most serious one. Therefore, a CRP to determine the imaging modality of ?? choice for the diagnosis and assessment of post-operative spinal infection would be extremely beneficial to further improve ???health care delivery in member states.??

          Objectives

          To assess the role of multimodality imaging (MRI, 99mTc-UBI SPECT/CT, [18F]FDG PET/CT) in the diagnosis of spinal infection after spinal surgery.

          Specific Objectives

          2 To determine if a specific imaging algorithm can be identified for the evaluation of spinal infection after spinal surgery.

          1. To determine and compare the diagnostic performance of MRI, 99mTc-UBI SPECT/CT and [18F]FDG PET/CT in the evaluation of suspected infection of the spine after surgery.

          Impact

          This CRP have :
          ? Increase knowledge of the medical community about the use of imaging in the diagnosis and assessment of post-operative spinal infection.
          ? Strengthen Radiology and Nuclear Medicine practice for the evaluation of suspected spinal infection in the participating centres.
          ? Demonstrate that the diagnostic performance of [18F] FDG PET/CT was similar to that of MRI and should lead to a wider use of this metabolic imaging modality, especially in diabetic patients suspected of osteomyelitis.
          ? Proposed a diagnostic imaging algorithm for postoperative spinal infection.

          Relevance

          Although 99mTc-UBI SPECT/CT was found to be disappointing and the most accurate imaging modality between MRI and [18F]FDG PET/CT remains uncertain, this CRP confirmed the importance of early diagnosis of post-operative spinal infections and the critical role played by imaging techniques.

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