Applications of Biological Dosimetry Methods in Radiation Oncology, Nuclear Medicine, and Diagnostic and Interventional Radiology (MEDBIODOSE)
Closed for Proposals
Project Type
Coordinated Research ProjectProject Code
E35010
CRP
2109
Approved Date
14/09/2016Project Status
ClosedStart Date
10/07/2017Expected End Date
09/07/2023Completed Date
09/01/2025Participating Countries
Argentina, Australia, Brazil, Canada, Chile, China, Cuba, France, United Kingdom of Great Britain and Northern Ireland, Ghana, Indonesia, Israel, India, Japan, Lithuania, Mexico, Philippines, Russian Federation, Saudi Arabia, Sudan, Singapore, Slovakia, Thailand, Ukraine, Uruguay, Viet Nam, South AfricaDescription
New title:Applications of biological dosimetry methods in radiation oncology, nuclear medicine, diagnostic and interventional radiology?Acronym: MEDBIODOSE?Biological dosimetry is one of the most developed branches of radiobiology; its technical aspects, particularly those relevant to cytogenetic assays, are well refined and have reached the level of the international standardisation. The aim of this CRP is to address various uses of biological dosimetry methods in radiation oncology, nuclear medicine, diagnostic and interventional radiology. It will include filing in gaps in knowledge and developing new approaches to assist with the transition to personalised medicine. The proposed CRP will build upon the success of a previous IAEA project E35008 on ‘Strengthening of “Biological dosimetry” in IAEA Member States: Improvement of current techniques and intensification of collaboration and networking among the different institutes’ (2012-2016)’. This project will bring together a number of institutions from LMI and HI MSs to progress toward the common goal of improving the quality of health care using radiation technologies.
Objectives
To sustain and enhance the scope of biodosimetry services to radiation oncology, nuclear medicine, diagnostic and interventional radiology.
Specific Objectives
Collect biodosimetry data on patients exposed to radiation for medical purposes to fill in knowledge gaps and assist with the transition to personalised medicine.
Establish a research biological dosimetry network for clinical applications.
Propose and test biodosimetry methodology for comprehensive assessment of consequences of medical radiation exposures, including accidental overexposure.
Develop biodosimetry based methods for prediction or prognosis of adverse radiotherapy effects and late complications allowing refinement of radiation treatment plans.
To facilitate dialogue between biodosimetry specialists and radiation oncologists.
To transfer biodosimetry methodology into clinical practice in order to improve outcome of radiation medical services in terms of survival, safety and quality of life.
Collect biodosimetry data on patients exposed to radiation for medical purposes to fill in knowledge gaps and assist with the transition to personalised medicine.
Establish a research biological dosimetry network for clinical applications.
Propose and test biodosimetry methodology for comprehensive assessment of consequences of medical radiation exposures, including accidental overexposure.
Develop biodosimetry based methods for prediction or prognosis of adverse radiotherapy effects and late complications allowing refinement of radiation treatment plans.
To facilitate dialogue between biodosimetry specialists and radiation oncologists.
To transfer biodosimetry methodology into clinical practice in order to improve outcome of radiation medical services in terms of survival, safety and quality of life.
Impact
This project complemented and reinforced efforts undertaken by the IAEA within the framework of the Technical Cooperation Programme and Coordinated Research Projects (CRPs) related to biodosimetry. It developed clinical applications of biodosimetric methods tailored for low and middle income countries, so that they benefit from a better, personalized medical service. Specifi cally, biological markers in radiation oncology can help in many areas, such as predicting tumour and normal tissue radiotherapy response. The project also helped countries to maintain and strengthen expertise in accident biodosimetry.
Relevance
High, it established a network of 60 participating institutions, with each participant having shared tasks related to the harmonization, strengthening and development of biodosimetric capability, and a specifi c CRP on the clinical application of biodosimetry.
CRP Publications
Cancer Research Institute, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of Sciences, Dúbravska cesta 9, 845 05 Bratislava, Slovakia
Paper
2020
Jakl, L., et al., Biodosimetry of Low Dose Ionizing Radiation Using DNA Repair Foci in Human Lymphocytes. Genes (Basel), 2020. 11(1).
Canada, Great Britain, Vietnam
Paper
2020
Shirley, B.C., et al., Estimating partial-body ionizing radiation exposure by automated cytogenetic biodosimetry. Int J Radiat Biol, 2020: p. 1–12.
IAEA, UN
News
2017
CRP E35008 Strengthening of “Biological Dosimetry” in IAEA Member States: Improvement of Current Techniques and Intensification of Collaboration and Networking Among the Different Institutes
Japan, Hiroshima University
Paper
2020
Sakane, H., M. Ishida, L. Shi, W. Fukumoto, C. Sakai, Y. Miyata, T. Ishida, T. Akita, M. Okada, K. Awai, and S. Tashiro, Biological Effects of Low-Dose Chest CT on Chromosomal DNA. Radiology, 2020, 295(2): p. 439-445.
IAEA, UN
News
2017
NEW CRP: Applications of Biological Dosimetry Methods in Radiation Oncology, Nuclear Medicine, Diagnostic and Interventional Radiology (E35010)
Grigoriev Institute for Medical Radiology, Ukraine and IAEA, UN
Paper
2019
Vinnikov, V. and O. Belyakov, Clinical Applications of Biomarkers of Radiation Exposure: Limitations and Possible Solutions through Coordinated Research. Radiat Prot Dosimetry, 2019.
Grigoriev Institute for Medical Radiology, Ukraine and IAEA, UN
Paper
2020
Vinnikov, V.A. and O. Belyakov, Radiation Exposure Biomarkers in the Practice of Medical Radiology: Cooperative Research and the Role of the International Atomic Energy Agency (IAEA) Biodosimetry/Radiobiology Laboratory. Health Phys, 2020, 119(1): p. 83-94.
Canada
Paper
2022
Mucaki, E.J., B.C. Shirley, and P.K. Rogan, Improved radiation expression profiling in blood by sequential application of sensitive and specific gene signatures. Int J Radiat Biol, 2022. 98(5): p. 924–941.
Sudan
Paper
2023
AMNA, A.A., et al., Phosphorylated P53 (TP53) in Cancer Patients Undergoing Radiotherapy, Journal of Pharmaceutical Research and Development 2023)
Grigoriev Institute for Medical Radiology, Ukraine and IAEA, UN
Paper
2019
Vinnikov, V. and O. Belyakov, Clinical Applications of Biomarkers of Radiation Exposure: Limitations and Possible Solutions through Coordinated Research. Radiat Prot Dosimetry, 2019.
CytoGnomix, Health Canada, Canadian Nuclear Laboratories, University of Western Ontario, Canada.
Paper
2019
Li, Y., B.C. Shirley, R.C. Wilkins, F. Norton, J.H.M. Knoll, and P.K. Rogan, Radiation Dose Estimation by Completely Automated Interpretation of the Dicentric Chromosome Assay. Radiat Prot Dosimetry, 2019.
CytoGnomix, Health Canada, Canadian Nuclear Laboratories, University of Western Ontario, Canada.
Paper
2019
Rogan, P., R. Lu, E. Mucaki, S. Ali, B. Shirley, Y. Li, R. Wilkins, F. Norton, O. Sevriukova, D. Pham, E. Ainsbury, J. Moquat, R. Cooke, T. Peerlaproulx, E. Waller, and J. Knoll, Automated Cytogenetic Biodosimetry at Population-Scale. bioRxiv, 2019: p. 718973
Japan
Paper
2020
Imano, N., et al., Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients. Radiat Res, 2020.
Canada, Great Britain, Lithuania
Paper
2021
Rogan, P.K., et al., Automated Cytogenetic Biodosimetry at Population-Scale. Radiation, 2021. 1(2): p. 79–94.
IAEA, UN
News
2017
CRP E35008 Strengthening of “Biological Dosimetry” in IAEA Member States: Improvement of Current Techniques and Intensification of Collaboration and Networking Among the Different Institutes
IAEA, UN
News
2017
NEW CRP: Applications of Biological Dosimetry Methods in Radiation Oncology, Nuclear Medicine, Diagnostic and Interventional Radiology (E35010)
Japan
Paper
2018
Shi, L., et al., Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure. Radiat Res, 2018. 190(4): p. 424–432.
Canada, Great Britain, Lithuania
Poster
2019
Rogan, PK, Shirley, BC, Li, Y, Guogyte, K, Sevriukova, O, Ngoc Duy, P. Knoll, JHM. (2019). Determination of Radiation Exposure Levels by Fully Automated Dicentric Chromosome Analysis: Results from IAEA MEDBIODOSE (CRP E35010) Inter-Laboratory Comparison.
Grigoriev Institute for Medical Radiology, Ukraine and IAEA, UN
Paper
2020
Vinnikov, V.A. and O. Belyakov, Radiation Exposure Biomarkers in the Practice of Medical Radiology: Cooperative Research and the Role of the International Atomic Energy Agency (IAEA) Biodosimetry/Radiobiology Laboratory. Health Phys, 2020, 119(1): p. 83-94.
CytoGnomix, Health Canada, Canadian Nuclear Laboratories, University of Western Ontario, Canada.
Paper
2019
Rogan, P., R. Lu, E. Mucaki, S. Ali, B. Shirley, Y. Li, R. Wilkins, F. Norton, O. Sevriukova, D. Pham, E. Ainsbury, J. Moquat, R. Cooke, T. Peerlaproulx, E. Waller, and J. Knoll, Automated Cytogenetic Biodosimetry at Population-Scale. bioRxiv, 2019: p. 718973
Japan, Hiroshima University
Paper
2020
Sakane, H., M. Ishida, L. Shi, W. Fukumoto, C. Sakai, Y. Miyata, T. Ishida, T. Akita, M. Okada, K. Awai, and S. Tashiro, Biological Effects of Low-Dose Chest CT on Chromosomal DNA. Radiology, 2020, 295(2): p. 439-445.
IAEA, UN
News
2020
Biodosimetry Helps Detect Radiosensitive Individuals – Interim Results of an IAEA Coordinated Research Project
CytoGnomix, Health Canada, Canadian Nuclear Laboratories, University of Western Ontario, Canada.
Paper
2019
Li, Y., B.C. Shirley, R.C. Wilkins, F. Norton, J.H.M. Knoll, and P.K. Rogan, Radiation Dose Estimation by Completely Automated Interpretation of the Dicentric Chromosome Assay. Radiat Prot Dosimetry, 2019.
IAEA, UN
News
2020
Biodosimetry Helps Detect Radiosensitive Individuals – Interim Results of an IAEA Coordinated Research Project
Indonesia, UK
Paper
2021
Basri, I.K.H., et al., Correlation between ? -H2AX, micronucleus and annual occupational dose in medical radiation workers. International Journal of Radiation Research, 2021. 19(4): p. 1015–1023.
India
Paper
2020
Yadav, U., et al., Multifaceted applications of pre-mature chromosome condensation in radiation biodosimetry. Int J Radiat Biol, 2020. 96(10): p. 1274–1280.