These guidelines were prepared by a multidisciplinary surgical/nuclear medicine/pathology expert panel under the joint auspices of the EANM Oncology Committee and the Sentinel European Node Trial Committee. The aim of this review is to provide evidence-based guidelines for the use of sentinel node biopsy as a staging tool in patients with early OSCC. 99mTc-labelled colloid pharmaceuticals are used as for LS in breast cancer and melanoma.