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          Instructive Surfaces and Scaffolds for Tissue Engineering Using Radiation Technology. (conducted jointly with F23030)

          Closed for proposals

          Project Type

          Coordinated Research Project

          Project Code

          E31007

          CRP

          2003

          Approved Date

          13 September 2013

          Status

          Closed

          Start Date

          4 April 2014

          Expected End Date

          30 April 2019

          Completed Date

          4 April 2019

          Participating Countries

          Russian Federation

          Description

          This CRP will support interested institutions in the preparation and testing of instructive scaffolds and surfaces using radiation technology to create tissue grafts and help to decrease the need for human donors. It could also be considered as a forum for information, knowledge and technology exchange among participating institutions and could facilitate the formation of a network of specialists from the diverse disciplines involved. Radiation technologies can play an important role in facilitating and accelerating the development of tissue engineering by addressing some of the challenges and opportunities involved, such as preparation/optimization of instructive scaffolds and their sterilization. The CRP is jointly conducted by the Division of Physical and Chemical Sciences (NAPC) and the Division of Human Health (NAHU) within the IAEA Department of Nuclear Sciences and Applications. While NAPC will implement the part related to the development and testing of the instructive surfaces and scaffolds, NAHU will carry out the biomedical application part related to the end uses of the instructive surfaces and scaffolds.

          Objectives

          is to engineer instructive scaffolds and surfaces using radiation technology to create tissues from autologous and allogeneic human somatic cells to provide tissue grafts and decrease the need for human donors.

          Specific objectives

          To bring together researchers from different research directions with end-users

          To investigate and optimize the preparation of instructive scaffolds and surfaces

          To investigate the use of radiation sterilization of the new instructive scaffolds and decellularized matrices

          To study cell-cell-scaffold-matrix-ECM interaction

          To study the possibilities and effectiveness of combining biological and non-biological materials on regeneration/repair

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